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  • Authors : Madabushi, Sowmya (2023)

  • Puromycin-sensitive aminopeptidase (E.C. 3.4.11.14, UniProt P55786), a zinc 6 metallopeptidase belonging to the M1 family, degrades a number of bioactive peptides as 7 well as peptides released from the proteasome, including polyglutamine. We report the 8 crystal structure of PSA at 2.3 Ǻ. Overall, the enzyme adopts a V-shaped architecture 9 with four domains characteristic of the M1 family aminopeptidases, but it is in a less 10...