Journal articleAuthors : Kishikawa, Jun-ichi (2023)
The Na+-pumping NADH-ubiquinone oxidoreductase (Na+-NQR) couples electron transfer
3 from NADH to ubiquinone with Na+-pumping, generating an electrochemical Na+ gradient that
4 is essential for energy-consuming reactions in bacteria. Since Na+-NQR is exclusively found in
5 prokaryotes, it is a promising target for highly selective antibiotics. However, the molecular
6 mechanism of inhibition is not well-understood for lack of the atomic structural informa...