Journal articleAuthors : McCorvie, Thomas J. (2023)
Cystathionine beta-synthase (CBS) is an essential metabolic enzyme across all
domains of life involved in the production of glutathione, cysteine, and hydrogen
sulphide1-4. Human CBS appends to its conserved catalytic domain a regulatory domain
that modulates activity by S-adenosyl-L-methionine (SAM) and promotes
oligomerization5-12, however the molecular basis is unknown. Here we show using
cryo-electron microscopy that full-length human CBS in the basa... 
