Journal ArticleAuthors : Mendoza, Johnny (2023)
Cobalamin-dependent methionine synthase (MS) is a key enzyme in methionine and folate one-carbon
metabolism. MS is a large multi-domain protein capable of binding and activating three substrates: homocysteine,
folate, S-adenosylmethionine for methylation. Achieving three chemically distinct methylations necessitates
significant domain rearrangements to facilitate substrate access to the cobalamin cofactor at the right time. The
distinct conformations required for each r... 
