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  • Journal article

  • Structure and function of a Notch-like proteolytic switch domain in the extracellular matrix receptor dystroglycan

    • Authors : Anderson, Michael J.M. (2023)

  • The adhesion receptor dystroglycan provides a critical mechanical link between the extracellular matrix (ECM) and the actin cytoskeleton to help muscle cells withstand contraction and neural cells maintain the blood brain barrier. Disrupting the link is associated cancer and muscular dystrophy. Proteolysis of dystroglycan by matrix metalloproteinases (MMPs) provides a mechanism to break the mechanical anchor and is amplified in several pathogenic states,&...
  • Journal article

  • Structure and function of a hexameric cyanophycin synthetase 2

    • Authors : Markus, Linda M. D.  (2023)

  • Cyanophycin is a natural polymer composed of a poly-aspartate backbone with arginine attached to each of the aspartate sidechains. Produced by a wide range of bacteria, which mainly use it as a store of fixed nitrogen, it has many promising industrial applications. Cyanophycin can be synthesized from the amino acids Asp and Arg by the widespread cyanophycin synthetase 1 (CphA1), or from the dipeptide β-Asp-Arg by the cyanobacteria...
  • Journal Article

  • Structure and function of a YeeE-YeeD complex for sophisticated thiosulfate uptake

    • Authors : Ikei, Mai (2023)

  • From bacteria to eukaryotes, sulfur is a vital element for cellular activities. For example, sulfur34 containing biomolecules, such as L-cysteine, L-methionine, thiamine, glutathione, and biotin, play a 35 variety of essential roles in cells (1). Bacteria and plants can utilize L-cysteine as a source of sulfate, 36 but they also have sulfur assimilation pathways to synthesize L-cysteine from inorganic sulfur 37 compounds. In bacteria, L-cysteine...