Tìm kiếm nâng cao

Current filters:

Current filters:

Discover

Search Results

  • previous
  • 1
  • next
Item hits:
  • Journal article

  • Structural insights into agonist-binding and activation of the human complement C3a receptor

    • Authors : Yadav, Manish K. (2023)

  • The complement cascade is an integral part of innate immunity, and it plays a crucial role in our body's innate immune response including combating microbial infections. Activation of the complement cascade results in the generation of multiple peptide fragments, of which complement C3a and C5a are potent anaphylatoxins. The complement C3a binds and activates a G protein-coupled receptor (GPCR) known as C3aR while C5a activates two distinct receptors...
  • Journal Article

  • Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

    • Authors : Yadav, Manish K. (2023)

  • The Hydroxycarboxylic acid receptor 2 (HCA2), also known as the niacin receptor or GPR109A, is a prototypical G protein-coupled receptor that plays a central role in the inhibition of lipolytic and atherogenic activities in our body. Interestingly, GPR109A activation also results in vasodilation that is linked to the side-effect of flushing associated with dyslipidemia drugs such as niacin. This receptor continues to be a key target for developing n...