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  • Journal Article

  • Cardiomyopathy-Associated Variants Alter the Structure and Function of the α-Actinin-2 Actin-Binding Domain

    • Authors : E Atang, Alexandra (2023)

  • Hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM) are characterized by thickening, thinning, or stiffening, respectively, of the ventricular myocardium, resulting in diastolic or systolic dysfunction that can lead to heart failure and sudden cardiac death. Recently, variants in the ACTN2 gene, encoding the protein α-actinin-2, have been reported in HCM, DCM, and RCM patients. However, functional data supporting the pathogenicit...
  • Journal article

  • Uncovering the structural flexibility of SARS-CoV-2 glycoprotein spike variants

    • Authors : Arruda, Hiam R. S. (2023)

  • The severe acute respiratory syndrome CoV-2 rapidly spread worldwide, causing a 43 pandemic. After a period of evolutionary stasis, a set of SARS-CoV-2 mutations has arisen in the 44 spike, the leading glycoprotein at the viral envelope and the primary antigenic candidate for 45 vaccines against the 2019 CoV disease (COVID-19). Here, we present comparative biochemical 46 data of the glycosylated full-length ancestral and D614G spike to...