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  • Journal article

  • Structural insights into agonist-binding and activation of the human complement C3a receptor

    • Authors : Yadav, Manish K. (2023)

  • The complement cascade is an integral part of innate immunity, and it plays a crucial role in our body's innate immune response including combating microbial infections. Activation of the complement cascade results in the generation of multiple peptide fragments, of which complement C3a and C5a are potent anaphylatoxins. The complement C3a binds and activates a G protein-coupled receptor (GPCR) known as C3aR while C5a activates two distinct receptors...
  • Industry article

  • Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease

    • Authors : gerber, janina Lara (2023)

  • RNA ligases of the RTCB-type play an essential role in tRNA splicing, the unfolded protein response and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA ligase complex. RNA ligation by the tRNA-ligase complex requires GTP-dependent activation of RTCB. This active site guanylylation reaction relies on the activation factor Archease. The mechanistic interplay between both proteins has remained unknown. Here, we report a&...
  • Journal article

  • Structural insights into the organization and channel properties of human Pannexin isoforms 1 and 3

    • Authors : Hussain, Nazia (2023)

  • Pannexins are single-membrane large-pore ion channels that release ATP upon activation. Three isoforms of pannexins, 1, 2, and 3, perform diverse cellular roles, including inflammation, differentiation, neuropathic pain, and ATP release. In this study, we report the cryoEM structure of pannexin 3 at 3.9 Å and characterize the structural differences with pannexin isoforms 1 and 2. We observe the organization of the Pannexin 3 vestibule into&...