OER - Kỹ thuật hóa học; Công nghệ sinh học - Thực phẩm; Công nghệ môi trường (1182)



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Collection's Items (Sorted by Submit Date in Descending order): 1 to 20 of 1182

  • OER000000779.pdf.jpg
  • Journal article


  • Authors : Pastor, Manuel Martín; Codeseira, Yaiza B; Spagnolli, Giovanni (2020)

  • PrPSc, the first described and most notorious prion, is the only protein known to cause epidemics of deadly disease. Its properties are encoded in its unique structure. Here we report a first solid state NMR study of a uniformly labelled (U-13C,15N)-Bank vole (BV) infectious recombinant PrPSc prion. C-C, C-H and N-H spectra were obtained with MAS rotation of the sample at up to 60 kHz. We obtained amino acid-type secondary structure i...

  • OER000000778.pdf.jpg
  • Journal article


  • Authors : Zhang, Qi; Aguilera, Javier; Reyes, Salvador Vazquez (2020)

  • EsxA has long been recognized as an important virulence factor of Mycobacterium tuberculosis (Mtb) that plays an essential role in Mtb cytosolic translocation presumably by penetrating phagosomal membranes with its acidic pH-dependent membrane permeabilizing activity (MPA). However, current data suggest that the observed cytolytic activity of EsxA at neutral pH is due to contamination of ASB-14, a detergent used in EsxA protein purification, and the role of&#...

  • OER000000418.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : - (2023)

  • Understanding the interconnection between energy, the environment, and the economy is critical in contemporary society. The relationship between energy consumption, economic growth, and the environment has garnered significant attention from researchers and policymakers alike, and understanding the underlying causal connection between energy and the economy is crucial for modeling effective environmental and growth policies. Moreover, the emergence of new energy and environmental...

  • OER000000776.pdf.jpg
  • Journal article


  • Authors : Iyamu, Iredia D; Huang, Rong (2020)

  • Methylation-mediated pathways play an important role in the progression of cancer. Inhibitors of several key methyltransferases including DNA methyltransferases and histone methyltransferases have proven to be instrumental for both understanding the function of the respective enzymes activites and translational applications in cancer epigenetic therapy. Nicotinamide N-methyltransferase (NNMT) is a major metabolic enzyme involved in epigenetic regulation through catalysis of methyl transfe...

  • OER000000775.pdf.jpg
  • Journal article


  • Authors : Vankadari, Naveen (2020)

  • The SARS-CoV-2 pandemic is an urgent global public health emergency and warrants investigating molecular and structural studies addressing the dynamics of viral proteins involved in host cell adhesion. The recent comparative genomic studies highlight the insertion of Furin protease site in the SARS-CoV-2 spike glycoprotein alerting possible modification in the viral spike protein and its eventual entry to host cell and presence of Furin site implicated to...

  • OER000000774.pdf.jpg
  • Journal article


  • Authors : Meireles, Diogo de Abreu; Yokomizo, César Henrique; Netto, Luís Eduardo Soares (-)

  • YbbN/CnoX are proteins that display a Trx domain linked to a tetratricopeptide (TPR) domain, which are involved in protein-protein interactions and protein folding processes. YbbN from Escherichia coli (EcYbbN) displays a co-chaperone (holdase) activity that is induced by HOCl (bleach). EcYbbN contains a SQHC motif within the Trx domain and displays no thiol-disulfide oxidoreductase activity. EcYbbN also presents a second Cys residue at Trx domain (Cys63)...

  • OER000000773.pdf.jpg
  • Keynote & speech


  • Authors : Diez, Ignacio Arribas; Govender, Ireshyn; Naicker, Previn (2020)

  • Phosphopeptide enrichment is an essential step in large-scale, quantitative phosphoproteomics studies by mass spectrometry. Several phosphopeptide affinity enrichment techniques exist, such as Immobilized Metal ion Affinity Chromatography (IMAC) and Metal Oxide Affinity Chromatography (MOAC). We compared Zirconium (IV) IMAC (Zr-IMAC) magnetic microparticles to more commonly used Titanium (IV) IMAC (Ti-IMAC) and TiO2 magnetic microparticles for phosphopeptide enrichment from simple and com...

  • OER000000772.pdf.jpg
  • Journal article


  • Authors : Zhang, Bo; Bowman, Courtney (-)

  • Many bacteria and other organisms form acetate during fermentation. Forming acetate from high energy-precursors (acetyl-CoA or acetyl phosphate) is one of the few ways that fermentative bacteria generate ATP. Here we found a biochemical pathway for forming acetate and synthesizing ATP that was unknown in bacteria. We found the bacterium Cutibacterium granulosum formed acetate during fermentation of glucose. With enzymatic assays, we showed it formed acetate u...

  • OER000000417_1.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : - (2021)

  • Glaciers and Polar regions provide important clues to understanding the past and present status of the Earth system, as well as to predict future forms of our planet. In particular, Antarctica, composed of an ice-covered continent in its center and the surrounding Sothern Ocean, has been gradually investigated during the last half century by all kinds of scientific branches; bioscience, physical sciences, geoscience, oceanography, environmental studies, toget...

  • OER000000417_1.pdf.jpg
  • Ebooks (Sách điện tử)


  • Authors : - (2021)

  • Glaciers and Polar regions provide important clues to understanding the past and present status of the Earth system, as well as to predict future forms of our planet. In particular, Antarctica, composed of an ice-covered continent in its center and the surrounding Sothern Ocean, has been gradually investigated during the last half century by all kinds of scientific branches; bioscience, physical sciences, geoscience, oceanography, environmental studies, toget...

  • OER000000416_1.pdf.jpg
  • -


  • Authors : - (2021)

  • The papers included in this Special Issue "Bioactive Molecules from Extreme Environments" provide an overview of the growing interest in species biodiversity, highlighting the importance of marine extreme environments as sources of a unique marine chemical diversity of molecules. It is worth noting that six articles in this Special Issue are focused on molecules and enzymes isolated from Antarctica. This means that there is a growing interest i...

  • OER000000763.pdf.jpg
  • Journal article


  • Authors : Smith, Tamar Cranford; Jamshad, Mohammed; Jeeves, Mark (2020)

  • The ATPase SecA is an essential component of the bacterial Sec machinery, which transports proteins across the cytoplasmic membrane. Most SecA proteins contain a long C-terminal tail (CTT). In Escherichia coli, the CTT contains a structurally flexible linker domain and a small metal-binding domain (MBD). The MBD coordinates zinc via a conserved cysteine-containing motif and binds to SecB and ribosomes.

  • OER000000762.pdf.jpg
  • Journal article


  • Authors : Dick, Jeffrey M; Yu, Miao; Tan, Jingqiang (2020)

  • Thermodynamic influences on the chemical compositions of proteins have remained enigmatic despite much work that demonstrates the impact of environmental conditions on amino acid frequencies. Here, we show that the dehydrating effect of salinity is apparent in protein sequences inferred from metagenomes and metatranscriptomes. The stoichiometric hydration state (nH2O), derived from the number of water molecules in theoretical reactions to form proteins from a particula...

  • OER000000761.pdf.jpg
  • Journal article


  • Authors : Kinavouidi, Duchel Jeanedvi Kinouani; Kayath, Christian Aimé; NGuimbi, Etienne (2020)

  • Biosurfactants are amphipathic molecules produced by many microorganisms, usually bacteria, fungi and yeasts. They possess the property of reducing the tension of the membrane interfaces. No studies have been conducted on Shigella species showing their involvement of biosurfactant like molecules (BLM) in pathogenicity. This study aims to show that environmental and clinical strains of Shigella are able to produce BLM by emulsifying gasoline and diesel fuels. ...

  • OER000000760.pdf.jpg
  • Journal article


  • Authors : Ramirez, Liliana Calzadiaz; Tusell, Carla Calvó; Stoffel, Gabriele M. M (2020)

  • Efficient regeneration of cofactors is vital for the establishment of continuous biocatalytic processes. Formate is an ideal electron donor for cofactor regeneration due to its general availability, low reduction potential, and benign byproduct (CO2). However, formate dehydrogenases (FDHs) are usual specific to NAD+, such that NADPH regeneration with formate is challenging. Previous studies reported naturally occurring FDHs or engineered FDHs that accept NADP+, but the...

  • OER000000759.pdf.jpg
  • Journal article


  • Authors : Chiapparino, Antonella; Giorgi, Francesca De; Scietti, Luigi (2020)

  • Hydroxylysine glycosylations are collagen-specific post-translational modifications essential for maturation and homeostasis of fibrillar as well as non-fibrillar collagen molecules. Lysyl hydroxylase 3 (LH3) is the only human enzyme capable of performing two chemically-distinct collagen glycosyltransferase reactions using the same catalytic site: inverting beta-1,O-galactosylation of hydroxylysines and retaining alpha-1,2-glycosylation of galactosyl hydroxylysines.

  • OER000000758.pdf.jpg
  • Journal article


  • Authors : Focht, Dorota; Neumann, Caroline; Lyons, Joseph (2020)

  • MhsT of Bacillus halodurans is a transporter of hydrophobic amino acids and a homologue of the eukaryotic SLC6 family of Na+-dependent symporters for amino acids, neurotransmitters, osmolytes, or creatine. The broad range of transported amino acids by MhsT prompted the investigation of the substrate recognition mechanism. Here, we report six new substrate-bound structures of MhsT, which, in conjunction with functional studies, reveal how the flexibility of a&...