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Title: | Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research |
Authors: | Reddy, Panga Jaipal. |
Keywords: | Borrelia PeptideAtlas; protein; chủng phổ biến; phân lập |
Issue Date: | 2023 |
Publisher: | bioRxiv |
Abstract: | Lyme disease , caused by an infection with the spirochete Borrelia burgdorferi, is the most common 36 vector-borne disease in North America. B. burgdorferi strains harbor extensive genomic and 37 proteomic variability and further comparison is key to understanding the spirochetes infectivity and 38 biological impacts of identified sequence variants. To achieve this goal, both transcript and mass 39 spectrometry (MS)-based proteomics was applied to assemble peptide datasets of laboratory 40 strains B31, MM1, B31-ML23, infective isolates B31-5A4, B31-A3, and 297, and other public 41 datasets, to provide a publicly available Borrelia PeptideAtlas 42 (http://www.peptideatlas.org/builds/borrelia/). Included is information on total proteome, 43 secretome, and membrane proteome of these B. burgdorferi strains. Proteomic data collected from 44 35 different experiment datasets, with a total of 855 mass spectrometry runs, identified 76,936 45 distinct peptides at a 0.1% peptide false-discovery-rate, which map to 1,221 canonical proteins (924 46 core canonical and 297 noncore canonical) and covers 86% of the total base B31 proteome. The 47 diverse proteomic information from multiple isolates with credible data presented by the Borrelia 48 PeptideAtlas can be useful to pinpoint potential protein targets which are common to infective 49 isolates and may be key in the infection process. |
URI: | http://dlib.hust.edu.vn/handle/HUST/23238 |
Link item primary: | https://www.biorxiv.org/content/10.1101/2023.06.16.545244v1.full.pdf+html |
Appears in Collections: | OER - Kỹ thuật hóa học; Công nghệ sinh học - Thực phẩm; Công nghệ môi trường |
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