Stress-Dependent Conformational Changes of Artemin: Effects of Heat and Oxidant

Abstract

There are a number of reports in which the chaperone-like activity of artemin, as a stress protein, has been confirmed in vivo and in vitro. Nonetheless, the details of structural changes of the protein have not been fully discovered yet. In the present work, we focused on conformational properties of artemin from A. urmiana upon exposing to heat and oxidation, by using various structural and functional analysis in order to predict the mechanisms of artemin’s activation. Notably, this is the first document on reporting the structural transitions of the chaperone in stress conditions.